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SET7/9 Protein Crystal(CBCRY57)

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Product Summary
Name SET7/9 Protein Crystal
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Cat No.CBCRY57
FragmentResidues 70-366
Protein DescriptionSET Domain Containing (Lysine Methyltransferase) 7
BackgroundHistone-lysine N-methyltransferase SETD7 belongs to histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. It plays a central role in the transcriptional activation of genes such as collagenase or insulin. It can be recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. SETD7 has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.
Protein ClassificationTransferase
Structure Weight33421.14 Da
MethodX-Ray Diffraction
Resolution2.30 Å
Ligand Chemical ComponentS-ADENOSYLMETHIONINE
ReferenceKwon T, Chang JH, Kwak E, Lee CW, Joachimiak A, Kim YC, Lee J, Cho Y. Mechanism of histone lysine methyl transfer revealed by the structure of set7/9-adomet. Embo J. (2003) 22 p.292

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