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AKT2 Protein Crystal(CBCRY43)

Product Summary
Name AKT2 Protein Crystal Download Datasheet
Background
Background AKT2 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase). Overexpression of this gene contributes to the malignant phenotype of a subset of human ductal pancreatic cancers.
Molecular Description
Protein ClassificationKinase
Structure Weight38884.90 Da
Polymer1
MoleculeRAC-BETA SERINE/THREONINE PROTEIN KINASE
Chain Length335 amino acids
Crystal Description
PDB ID1GZN
MMDB ID22886
SourceInsect cells
MethodX-Ray Diffraction
Resolution2.50 Å
Gene Information
Gene NameAKT2
SynonymsPKBB; PRKBB; HIHGHH; PKBBETA; RAC-BETA
UniProt IDP31751
Gene ID208
Chromosome Location19q13.1-q13.2
FunctionATP binding; kinase activity; protein serine/threonine kinase activity
Reference
Reference Yang J, Cron P, Thompson V, Good V, Hess D, Hemmings BA, Barford D. Molecular mechanism for the regulation of protein kinase b/akt by hydrophobic motif phosphorylation. Mol.Cell (2002) 9 p.1227

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