DAAO Protein Crystal

Background

This gene encodes the peroxisomal enzyme D-amino acid oxidase. The D-amino acid oxidase is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. It regulates the level of the neuromodulator D-serine in the brain, has high activity towards D-DOPA and contributes to dopamine synthesis.

Protein Classification

Oxidoreductase

Structure Weight

161715.92 Da

Polymer

1

Molecule

D-amino-acid oxidase

Chain Length

347 amino acids

PDB ID

2DU8

MMDB ID

42655

Source

E.coli

Method

X-Ray Diffraction

Resolution

2.50 Å

Ligand Chemical Component

BEZ, FAD

Gene Name

DAO

Synonyms

DAAO; OXDA; DAMOX

UniProt ID

P14920

Gene ID

1610

Chromosome Location

12q24

Function

cofactor binding; D-amino-acid oxidase activity; FAD binding; protein dimerization activity; receptor binding

Reference

Kawazoe T, Tsuge H, Pilone MS, Fukui K. Crystal structure of human d-amino acid oxidase: context-dependent variability of the backbone conformation of the vaagl hydrophobic stretch located at the si-face of the flavin ring. Protein Sci. (2006) 15 p.2708