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DAAO Protein Crystal(CBCRY46)

Product Summary
Name DAAO Protein Crystal Download Datasheet
Background
Background This gene encodes the peroxisomal enzyme D-amino acid oxidase. The D-amino acid oxidase is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. It regulates the level of the neuromodulator D-serine in the brain, has high activity towards D-DOPA and contributes to dopamine synthesis.
Molecular Description
Protein ClassificationOxidoreductase
Structure Weight161715.92 Da
Polymer1
MoleculeD-amino-acid oxidase
Chain Length347 amino acids
Crystal Description
PDB ID2DU8
MMDB ID42655
SourceE.coli
MethodX-Ray Diffraction
Resolution2.50 Å
Ligand Chemical ComponentBEZ, FAD
Gene Information
Gene NameDAO
SynonymsDAAO; OXDA; DAMOX
UniProt IDP14920
Gene ID1610
Chromosome Location12q24
Functioncofactor binding; D-amino-acid oxidase activity; FAD binding; protein dimerization activity; receptor binding
Reference
Reference Kawazoe T, Tsuge H, Pilone MS, Fukui K. Crystal structure of human d-amino acid oxidase: context-dependent variability of the backbone conformation of the vaagl hydrophobic stretch located at the si-face of the flavin ring. Protein Sci. (2006) 15 p.2708

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