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Product Summary | |
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Name | EphA2 Protein Crystal Download Datasheet |
Background | |
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Background | Ephrin type-A receptor 2 belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. It regulates cell adhesion and differentiation and also participates in UV radiation-induced apoptosis. Mutations in this gene are the cause of certain genetically-related cataract disorders. |
Molecular Description | |
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Protein Classification | Receptor |
Structure Weight | 60679.26 Da |
Polymer | 1 |
Molecule | Ephrin type-A receptor 2 |
Chain Length | 545 amino acids |
Crystal Description | |
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PDB ID | 2X10 |
MMDB ID | 80766 |
Source | Homo sapiens |
Method | X-Ray Diffraction |
Resolution | 3.00 Å |
Ligand Chemical Component | Cl-, NAG |
Gene Information | |
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Gene Name | EPHA2 |
Synonyms | ECK; CTPA; ARCC2; CTPP1; CTRCT6 |
UniProt ID | P29317 |
Gene ID | 1969 |
Chromosome Location | 1p36 |
Function | ATP binding; ephrin receptor activity; transmembrane receptor protein tyrosine kinase activity |
Reference | |
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Reference | Seiradake E, Harlos K, Sutton G, Aricescu AR, Jones EY. An extracellular steric seeding mechanism for eph- ephrin signalling platform assembly. Nat.Struct.Mol.Biol. (2010) 17 p.398 |