Ephrin type-A receptor 2 belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. It regulates cell adhesion and differentiation and also participates in UV radiation-induced apoptosis. Mutations in this gene are the cause of certain genetically-related cataract disorders.
Molecular Description
Protein Classification
Receptor
Structure Weight
60679.26 Da
Polymer
1
Molecule
Ephrin type-A receptor 2
Chain Length
545 amino acids
Crystal Description
PDB ID
2X10
MMDB ID
80766
Source
Homo sapiens
Method
X-Ray Diffraction
Resolution
3.00 Å
Ligand Chemical Component
Cl-, NAG
Gene Information
Gene Name
EPHA2
Synonyms
ECK; CTPA; ARCC2; CTPP1; CTRCT6
UniProt ID
P29317
Gene ID
1969
Chromosome Location
1p36
Function
ATP binding; ephrin receptor activity; transmembrane receptor protein tyrosine kinase activity
Reference
Reference
Seiradake E, Harlos K, Sutton G, Aricescu AR, Jones EY. An extracellular steric seeding mechanism for eph- ephrin signalling platform assembly. Nat.Struct.Mol.Biol. (2010) 17 p.398
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