EphA2 Protein Crystal

Background

Ephrin type-A receptor 2 belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. It regulates cell adhesion and differentiation and also participates in UV radiation-induced apoptosis. Mutations in this gene are the cause of certain genetically-related cataract disorders.

Protein Classification

Receptor

Structure Weight

60679.26 Da

Polymer

1

Molecule

Ephrin type-A receptor 2

Chain Length

545 amino acids

PDB ID

2X10

MMDB ID

80766

Source

Homo sapiens

Method

X-Ray Diffraction

Resolution

3.00 Å

Ligand Chemical Component

Cl-, NAG

Gene Name

EPHA2

Synonyms

ECK; CTPA; ARCC2; CTPP1; CTRCT6

UniProt ID

P29317

Gene ID

1969

Chromosome Location

1p36

Function

ATP binding; ephrin receptor activity; transmembrane receptor protein tyrosine kinase activity

Reference

Seiradake E, Harlos K, Sutton G, Aricescu AR, Jones EY. An extracellular steric seeding mechanism for eph- ephrin signalling platform assembly. Nat.Struct.Mol.Biol. (2010) 17 p.398