Promise

Our promise to you: Guaranteed product quality, expert customer support.

EphA2 Protein Crystal(CBCRY49)

Product Summary
Name EphA2 Protein Crystal Download Datasheet
Background
Background Ephrin type-A receptor 2 belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. It regulates cell adhesion and differentiation and also participates in UV radiation-induced apoptosis. Mutations in this gene are the cause of certain genetically-related cataract disorders.
Molecular Description
Protein ClassificationReceptor
Structure Weight60679.26 Da
Polymer1
MoleculeEphrin type-A receptor 2
Chain Length545 amino acids
Crystal Description
PDB ID2X10
MMDB ID80766
SourceHomo sapiens
MethodX-Ray Diffraction
Resolution3.00 Å
Ligand Chemical ComponentCl-, NAG
Gene Information
Gene NameEPHA2
SynonymsECK; CTPA; ARCC2; CTPP1; CTRCT6
UniProt IDP29317
Gene ID1969
Chromosome Location1p36
FunctionATP binding; ephrin receptor activity; transmembrane receptor protein tyrosine kinase activity
Reference
Reference Seiradake E, Harlos K, Sutton G, Aricescu AR, Jones EY. An extracellular steric seeding mechanism for eph- ephrin signalling platform assembly. Nat.Struct.Mol.Biol. (2010) 17 p.398

Online Inquiry

  • Verification code
    Click image to refresh the verification code.