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EphA2 Protein Crystal(CBCRY49)

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Product Summary
Name	EphA2 Protein Crystal Download Datasheet

Background
Background	Ephrin type-A receptor 2 belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. It regulates cell adhesion and differentiation and also participates in UV radiation-induced apoptosis. Mutations in this gene are the cause of certain genetically-related cataract disorders.

Background

Ephrin type-A receptor 2 belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. It regulates cell adhesion and differentiation and also participates in UV radiation-induced apoptosis. Mutations in this gene are the cause of certain genetically-related cataract disorders.

Molecular Description
Protein Classification	Receptor
Structure Weight	60679.26 Da
Polymer	1
Molecule	Ephrin type-A receptor 2
Chain Length	545 amino acids

Crystal Description
PDB ID	2X10
MMDB ID	80766
Source	Homo sapiens
Method	X-Ray Diffraction
Resolution	3.00 Å
Ligand Chemical Component	Cl-, NAG

Gene Information
Gene Name	EPHA2
Synonyms	ECK; CTPA; ARCC2; CTPP1; CTRCT6
UniProt ID	P29317
Gene ID	1969
Chromosome Location	1p36
Function	ATP binding; ephrin receptor activity; transmembrane receptor protein tyrosine kinase activity

Reference
Reference	Seiradake E, Harlos K, Sutton G, Aricescu AR, Jones EY. An extracellular steric seeding mechanism for eph- ephrin signalling platform assembly. Nat.Struct.Mol.Biol. (2010) 17 p.398

EphA2 Protein Crystal

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EphA2 Protein Crystal(CBCRY49)

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