Background

Neurotrophins (NTs) are important regulators for the survival, differentiation and maintenance of different peripheral and central neurons. NTs bind to two distinct classes of glycosylated receptor: the p75 neurotrophin receptor (p75(NTR)) and tyrosine kinase receptors (Trks). Whereas p75(NTR) binds to all NTs, the Trk subtypes are specific for each NT.

Protein Classification

signaling protein

Structure Weight

63861.22 Da

Polymer

1

Molecule

Neurotrophin-3

Chain Length

119 amino acids

Polymer

2

Molecule

Tumor necrosis factor receptor superfamily member 16

Chain Length

167 amino acids

PDB ID

3BUK

MMDB ID

65479

Source

E.coli

Method

X-Ray Diffraction

Resolution

2.6Å

Ligand Chemical Component

N-Acetyl-D-Glucosamine

Gene Name

NTF3

Synonyms

HDNF; MGC129711; NGF-2; NGF2; NT3; Nerve growth factor 2; neurotrophic factor; neurotrophin 3

UniProt ID

P20783

Gene ID

4908

Chromosome Location

12p13

Function

growth factor activity; nerve growth factor binding; neurotrophin receptor binding

Gene Name

NGFR

Synonyms

CD271; Gp80-LNGFR; TNFRSF16; p75(NTR); p75NTR; low affinity nerve growth factor receptor; low-affinity nerve growth factor receptor; nerve growth factor receptor; CD271 antigen; NGF receptor; nerve growth factor receptor

UniProt ID

P08138

Gene ID

4804

Chromosome Location

17q21-q22

Function

death receptor activity; nerve growth factor binding; protein binding

Reference

Gong, Y., Cao, P., Yu, H.J., Jiang, T. (2008) Crystal structure of the neurotrophin-3 and p75NTR symmetrical complex. Nature 454: 789-793