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PI3Kα Protein Crystal(CBCRY44)

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Product Summary
Name PI3Kα Protein Crystal
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Cat No.CBCRY44
Fragmentcatalytic subunit alpha isoform
Protein DescriptionPhosphoinositide 3 Kinase Alpha
BackgroundPhosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers.
Protein ClassificationTransferase/oncoprotein
Structure Weight161490.30 Da
MethodX-Ray Diffraction
Resolution3.05 Å
ReferenceHuang CH, Mandelker D, Schmidt-Kittler O, Samuels Y, Velculescu VE, Kinzler KW, Vogelstein B, Gabelli SB, Amzel LM. The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic pi3kalpha mutations. Science (2007) 318 p.1744

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