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DNCL2A Protein Crystal(CBCRY31)

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Product Summary
Name DNCL2A Protein Crystal
Download Datasheet
Cat No.CBCRY31
FragmentFull length
Protein DescriptionDynein Light Chain Dnlc2a
BackgroundThe human light chain of the motor protein dynein, Dnlc2A, is also a novel TGF-beta-signaling component, which is altered with high frequency in epithelial ovarian cancer. It is an important mediator of dynein and the development of cancer, owing to its ability to bind to the dynein intermediate light chain (DIC) IC74 and to regulate TGF-beta-dependent transcriptional events.
Protein ClassificationTransport Protein
Structure Weight24324.71 Da
MethodX-Ray Diffraction
Resolution2.10Å
Ligand Chemical ComponentCesium ion
ReferenceLiu, J.-F., Wang, Z.-X., Wang, X.-Q., Tang, Q., An, X.-M., Gui, L.-L., Liang, D.-C. (2006) Crystal structure of human dynein light chain Dnlc2A: Structural insights into the interaction with IC74 Biochem.Biophys.Res.Commun. 349: 1125-1129

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