NMR of Paramagnetic Compounds

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Paramagnetic NMR spectroscopy refers to the nuclear magnetic resonance (NMR) spectroscopy of paramagnetic compounds. Although most NMR measurements are carried out on paramagnetic compounds, paramagnetic samples can also be analyzed and have special effects, which are manifested in the wide range of chemical shifts and the broadening of signals. However, the spectra of paramagnetic compounds provide insight into the combination and structure of samples.

Paramagnetic ions and molecules have been widely used as external displacement and relaxation probes to study the structure and dynamics of biomolecules.

As an expert in the field of nuclear magnetic resonance, Creative Biostructure uses paramagnetic nuclear magnetic resonance spectroscopy to provide customers with chemical and structural biology research services of paramagnetic compounds, as well as protein structure, dynamics, and interaction analysis services.

Figure 1. Paramagnetic vs. Diamagnetic Substances (PSIBERG Team, 2022)

Why Use Paramagnetic NMR

Paramagnetic nuclear magnetic resonance spectroscopy is the core of many fields, from the study of the structure, dynamics and interaction of proteins in chemistry and structural biology, to the detection of spin groups in spin-crossing compounds, as well as paramagnetic complexes and supramolecular structures. Compared with diamagnetic NMR spectrum, paramagnetic NMR spectrum also has advantages.

The large paramagnetic shift leads to the dispersion of NMR signals in a wider range of chemical shifts, resulting in a reduction in the possibility of signal overlap.

Compared with diamagnetic compounds, the short relaxation time of paramagnetic compounds can reduce the repetition delay and acquisition time, thus significantly reducing the experimental time or collecting more data in a similar time.

The structural information can also be observed by paramagnetic nuclear magnetic resonance spectrum, which is not observed in antimagnetic analogues.

Obtained Information from Paramagnetic NMR

Metal oxidation state and spin state
Electron spin relaxation time (estimate)
Presence of low-lying excited states
Pattern and amount of electron spin delocalization onto ligands; hyperfine coupling constants
Presence of hydrogen bonds
Magnetic anisotropy, magnetic axes
Structural refinement
3D structure, exchange phenomena, dynamics, etc.

Service Applications

Electronic Structure & Spin Distribution
Stereochem and Structure
Equilibrium Dynamics & Solvation
Lanthanide Shift Reagents
Bioinorganic Applications
Contrast agents for MRI

Creative Biostructure is committed to providing high-quality NMR analysis services to advance the life sciences fields. If you have any questions or needs, please contact us and our customer service staff will help you the first time.

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