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Product Summary
Fragment
Polo box domain
Protein Description
Polo-like Kinase 1
Background
Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. The Ser/Thr protein kinase belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of this protein in cancer cells dramatically inhibited cell proliferation and induced apoptosis; hence, it is a target for cancer therapy.
Protein Classification
Transferase
Structure Weight
54544.60 Da
PDBID
1Q4O
Method
X-Ray Diffraction
Resolution
2.20 Å
Reference
Cheng KY, Lowe ED, Sinclair J, Nigg EA, Johnson LN. The crystal structure of the human polo-like kinase-1 polo box domain and its phospho-peptide complex. Embo J. (2003) 22 p.5757
cDNALength
1809