Exosome Lipidomics & Metabolomics

Creative Biostructure has long been focused on the research related to disease. We offer comprehensive analytical services for exosome lipidomics and metabolomics, which support you to find potential biomarkers much easier.

The Importance of Exosome Lipidomics & Metabolomics Analysis

Exosomes contain various compositions, including proteins, nucleic acids, lipids, and other metabolites, which facilitating cell-to-cell communication. In vivo cells, lipids usually act as medium for signal transduction. More importantly, exosomes contain several unique lipids compared with recipient cells, which may be used as novel biomarkers for disease diagnosis and prognosis. In addition to lipids, exosomes also carry a wide range of other metabolites that take an active role in cancer progression and can also be used for biomarker discovery. Therefore, the monitoring of exosome lipidomics and metabolomics is important to study the onset and progression of metabolic diseases. Given that lipid and metabolite contents of exosomes differ from the parent cells and also change during physiological processes, characterizing lipidomics of different biofluids is the most possible way to find out the sensitive and specific biomarkers.

Exosome Lipidomics & Metabolomics service

Creative Biostructure supports accurate and sensitive detection of metabolites from exosomes, which facilitates the exploration of biomarker screening. We have specialized experts and well-established platforms that allow getting the most information from your exosomes quickly and efficiently. Advantages of our exosome lipidomics and metabolomics service are as follows:

• Effective sample isolation. We provide the optimal method for exosome isolation for different input samples, including cells, culture supernatant, plasma (whole blood, serum), etc..
• Diverse identification of exosomes. We also offer tailored solutions for morphology, particle size, exosomes markers, label and tracking analysis.
• High throughput analysis. We provide professional exosome lipidomics and metabolimics analysis services with reliable and sensitive results using cutting-edge technologies. These technologies include thin layer chromatography (TLC), high performance liquid chromatography (HPLC), NMR spectroscopy, mass spectrometry, reverse phase chromatography, etc..
• Rapid delivery time with detailed project report.
• Professional communication and competitive prices.

Figure 1 Characterization of the metabolite content of human plasma Exosome-Like Vesicles (P ELVs) (Panel A) or PANC 1 cell culture media (CCM ELVs) (Panel B). (Altadill et al., 2016)

Creative Biostructure focuses on cost-effective, high throughput biomarker development of diseases. We hope our work could add value to clinical and translational studies. We will continue to develop innovative ways to meet your requirements in biomarker discovery areas. Please feel free to contact us for more details and find out how it helps your research.

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References:

1. Kumari S.; Singh A. Urinary exosomal lipidomics reveals markers for diabetic nephropathy. Current metabolomics. 2018, 6(2): 131-139.
2. Tatiana Altadill T.; Campoy I. Enabling metabolomics based biomarker discovery studies using molecular phenotyping of exosome-like vesicles. PLOS One. 2016, 11(3): e0151339.