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Product Summary
Fragment
Full length
Protein Description
Pyrroline-5-carboxylate Reductase 2
Background
Pyrroline-5-carboxylate reductase (P5CR) is a universal housekeeping enzyme that catalyzes the reduction of Delta(1)-pyrroline-5-carboxylate (P5C) to proline using NAD(P)H as the cofactor. The enzymatic cycle between P5C and proline is very important for the regulation of amino acid metabolism, intracellular redox potential, and apoptosis
Protein Classification
Oxidoreductase
Structure Weight
149791.08 Da
PDBID
2GR9
Method
X-Ray Diffraction
Resolution
3.1Å
Ligand Chemical Component
Magnesium ion; Sulfate ion
Reference
Meng, Z., Lou, Z., Liu, Z., Li, M., Zhao, X., Bartlam, M., Rao, Z. (2006) Crystal structure of human pyrroline-5-carboxylate reductase J.Mol.Biol. 359: 1364-1377
cDNALength
831