Background

p21 protein (Cdc42/Rac)-activated kinase 1 belongs to the family of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. Protein kinase regulates cell motility and morphology, and plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes.

Protein Classification

Transferase

Structure Weight

88460.94 Da

Polymer

1

Molecule

SERINE/THREONINE-PROTEIN KINASE PAK-ALPHA AUTOREGULATORY DOMAIN

Chain Length

80 amino acids

Polymer

2

Molecule

SERINE/THREONINE-PROTEIN KINASE PAK-ALPHA KINASE DOMAIN

Chain Length

297 amino acids

PDB ID

1F3M

MMDB ID

13568

Source

E.coli

Method

X-Ray Diffraction

Resolution

2.30 Å

Ligand Chemical Component

IODIDE ION

Gene Name

PAK1

Synonyms

PAKalpha; Alpha-PAK; p21-activated kinase 1; p65-PAK

UniProt ID

Q13153

Gene ID

5058

Chromosome Location

11q13-q14

Function

ATP binding;collagen binding; protein kinase activity; protein serine/threonine kinase activity; Rac GTPase binding

Gene Name

PAK1

Synonyms

PAKalpha; Alpha-PAK; p21-activated kinase 1; p65-PAK

UniProt ID

Q13153

Gene ID

5058

Chromosome Location

11q13-q14

Function

ATP binding;collagen binding; protein kinase activity; protein serine/threonine kinase activity; Rac GTPase binding

Reference

Lei M, Lu W, Meng W, Parrini MC, Eck MJ, Mayer BJ, Harrison SC. Structure of pak1 in an autoinhibited conformation reveals a multistage activation switch. Cell(Cambridge,Mass.) (2000) 102 p.387