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PAK1 Protein Crystal(CBCRY51)

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Product Summary
Name PAK1 Protein Crystal Download Datasheet
Background
Background p21 protein (Cdc42/Rac)-activated kinase 1 belongs to the family of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. Protein kinase regulates cell motility and morphology, and plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes.
Molecular Description
Protein ClassificationTransferase
Structure Weight88460.94 Da
Polymer1
MoleculeSERINE/THREONINE-PROTEIN KINASE PAK-ALPHA AUTOREGULATORY DOMAIN
Chain Length80 amino acids
Polymer2
MoleculeSERINE/THREONINE-PROTEIN KINASE PAK-ALPHA KINASE DOMAIN
Chain Length297 amino acids
Crystal Description
PDB ID1F3M
MMDB ID13568
SourceE.coli
MethodX-Ray Diffraction
Resolution2.30 Å
Ligand Chemical ComponentIODIDE ION
Gene Information
Gene NamePAK1
SynonymsPAKalpha; Alpha-PAK; p21-activated kinase 1; p65-PAK
UniProt IDQ13153
Gene ID5058
Chromosome Location11q13-q14
FunctionATP binding;collagen binding; protein kinase activity; protein serine/threonine kinase activity; Rac GTPase binding
Reference
Reference Lei M, Lu W, Meng W, Parrini MC, Eck MJ, Mayer BJ, Harrison SC. Structure of pak1 in an autoinhibited conformation reveals a multistage activation switch. Cell(Cambridge,Mass.) (2000) 102 p.387

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