Creative Biostructure has access to advanced super-resolution light microscopy facility allowing images to be taken with a higher resolution than the diffraction limit. Super-resolution microscopy is a form of light microscopy, which can be applied to observe many biological structures not resolvable in conventional fluorescence microscopy. For example, new advances in this technique now give them the ability to image three-dimensional (3D) structures, measure interactions by multicolor colocalization, and record dynamic processes in living cells at the nanometer scale.
Figure 1. Examples of super-resolution images of biological samples.
Several far-field imaging methods are known to extend the diffraction-limited resolution to smaller values:
Figure 2. The principle of STED microscopy.
Applications in Super-Resolution Microscopy technology:
Super-resolution fluorescence microscopy has shown great promise and ability in studying biological structures and processes at the cellular to macromolecular scale. Images obtained from these new super-resolution approaches will enable scientists to directly visualize biological samples at the nanometer scale and will complement the insights obtained through traditional molecular and cell biology approaches, significantly expanding our understanding of molecular interactions and dynamic processes in living systems. Please feel free to contact us for a detailed quote.