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Using dual approach has emerged as a novel plan to tackle the problems of poor aqueous solubility and low rate of dissolution in drug formulation. Therefore, Creative Biostructure combines the cyclodextrins and nanotechnology to develop cyclodextrin-based liposomes that deliver hydrophobic drugs.
How Cyclodextrin-Based Liposomes Work
Cyclodextrins (CDs) are cyclic oligosaccharides formed from glucopyranose units. With hydrophobic cavity inside and hydrophilic outside, they can form complexes with hydrophobic compounds. The CD/drug inclusion complex provide an alternative approach to encapsulate hydrophobic drugs in the aqueous phase of liposome instead of incorporating them into the phospholipids membrane bilayers. This double-loading technique provides better therapeutic effects in the following aspects.
Cyclodextrin-Based Liposomes Applications
Cyclodextrin-based liposomes is a promising carrier system to preserve volatile and hydrophobic drugs; and provide an access to explore their applications in pharmaceutical, cosmetic and food industry. In addition to liposomes, cyclodextrin-based nanocarriers could be expanded by combination with other carriers like niosomes, nanosponges, micelles, Short Interfering RNA, etc. This complementary carrier system could broaden the scope and accessibility of present and future therapeutic agents.
Creative Biostructure presents our well-developed cyclodextrin-based liposomes technology, which offers the best, customized service to your research:
Figure 1. Cyclodextrin-based liposomes (International Journal of Pharmaceutics. 2014)
Several anti-cancer and anti-inflammatory drugs are developed using cyclodextrin-based liposomes technology. Creative Biostructure offers an advanced liposome manufacturing platform to promote the development of novel drugs. Having an excellent record of designing, producing, and analyzing CD-based liposomes, the quality of our service is endorsed by hundreds of customers.
Please contact us for more details and find out how it helps to the new product development.