Creative Biostructure can provide rapid, sensitive and reliable assays using MagHelix™ SPR for applications such as affinity measurement, pharmacokinetics (PK), toxicokinetics (TK), immunogenicity, biological potency testing (batch release and stability testing), drug screening, etc. We have rich experiences with SPR and serve many customers in the pharmaceutical industry at design and subsequent phases. We can help you with application optimization for many different projects.
Our MagHelix™ SPR is a powerful optional detection platform and can obtain label-free quality data in real-time to monitor biomolecular interactions. Biacore and Fortebio systems are two most widely used tools based on SPR technology to monitor biomolecular interactions (e.g., antigen-antibody affinity, protein-small molecule, protein-peptide and protein-protein).
Figure 1.The changes in the refractive index in the immediate vicinity of the surface layer of a sensor chip can be detected by SPR.
Figure 2: Next-generation SPR instrumentation (Biochim Biophys Acta. 2014)
Our MagHelix™ analytical methods for biophysical characterization of biomolecules include but are not limited to:
Cooper MA. Optional biosensors in drug discovery. Nature Review Drug Discovery. 2002 Jul; 1 (7): 515-28.
Simon G. Patching. Surface plasmon resonance spectroscopy for characterisation of membrane protein–ligand interactions and its potential for drug discovery. Biochim Biophys Acta. 2014 Jan;1838(1 Pt A):43-55.