How FATHOM® EPR Unlocks Missing Dynamics in Integrative Structural Biology
10AM EDT | 4PM CEST, August 18, 2026
Cryo-EM and X-ray crystallography provide high-resolution structural snapshots, while AI-based prediction tools such as AlphaFold generate increasingly accurate structural models. However, these approaches may not fully reveal the conformational motion, structural heterogeneity, and dynamic molecular interactions that govern biological function.
Creative Biostructure and High Q Technologies invite you to explore how quantum-enabled FATHOM® Electron Paramagnetic Resonance (EPR) adds the missing dynamic dimension to integrative structural biology.
In this webinar, Dr. Xinyan Zhang of Creative Biostructure and Austin Gamble Jarvi of High Q Technologies will introduce how FATHOM® EPR measures site-specific distance distributions, conformational states, and molecular dynamics. By generating direct experimental constraints, FATHOM® EPR can complement Cryo-EM, crystallography, NMR, HDX-MS, molecular modeling, and AI-predicted structures.
The speakers will discuss how EPR data can help researchers identify flexible regions, distinguish conformational populations, investigate protein–protein and protein–ligand interactions, and validate structural models that cannot be fully resolved using static methods alone.
Key Points to Be Discussed During the Session
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Why static structures and predicted models may not capture functionally important molecular dynamics
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How FATHOM® EPR measures conformational distributions and nanoscale distance changes
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How experimental EPR data can validate, refine, and complement Cryo-EM, crystallography, and AlphaFold models
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Applications in protein conformational analysis, interaction studies, membrane protein research, and drug discovery
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How FATHOM® EPR can be integrated with complementary structural and biophysical techniques
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Considerations for sample preparation, spin labeling, experimental design, data collection, and interpretation
Join us to discover how FATHOM® EPR can bridge the gap between predicted or static structures and the dynamic biological behavior of proteins, providing experimental ground-truth data for more complete and reliable structural interpretation.
Explore the FATHOM® EPR Spectroscopy Platform
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Speaker
Dr. Zhang specializes in advanced structural biology, with expertise spanning biophysical characterization, recombinant protein expression, native protein complex extraction, and high-resolution structural techniques such as Cryo-EM.
Before joining Creative Biostructure, Dr. Zhang conducted postdoctoral research at Harvard Medical School, where he further developed his expertise in structural biology. In his current role, he connects laboratory research with practical commercial applications, overseeing protein purification and biophysical characterization projects while supporting business development, scientific partnerships, and customized research solutions.
As Applications Manager at High Q Technologies, Dr. Jarvi develops new EPR applications for structural biology research and drug discovery. He is committed to demonstrating the versatility of EPR and supporting its broader adoption across biomedical research and industrial development.
Dr. Jarvi is passionate about spectroscopy, scientific instrumentation, and delivering an exceptional end-user experience. Before joining High Q Technologies, he completed his Ph.D. at the University of Pittsburgh, where his research focused on the development of EPR spin labels and their applications.
His background in EPR methodology, spin-label design, and biophysical research provides a strong technical foundation for bringing advanced EPR capabilities to the forefront of structural biology.
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