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3CLpro Protein Crystal(CBCRY05)

Product Summary
Name 3CLpro Protein Crystal Download Datasheet
Background
Background The SARS-CoV main protease, which is a 33.8-kDa protease (also called the 3C-like protease), plays a pivotal role in mediating viral replication and transcription functions through extensive proteolytic processing of two replicase polyproteins, pp1a (486 kDa) and pp1ab (790 kDa).
Molecular Description
Protein ClassificationHydrolase
Structure Weight69623.62 Da
Polymer1
Molecule3C-like proteinase
Chain Length306 amino acids
Polymer2
Molecule5-mer peptide of inhibitor
Chain Length5 amino acids
Crystal Description
PDB ID1UK4
MMDB ID25518
SourceE.coli
MethodX-Ray Diffraction
Resolution2.5 Å
Ligand Chemical ComponentChloroacetone
Gene Information
Gene NameNEWENTRY
Synonyms3C-like proteinase
Gene ID2831005
FunctionRNA binding; catalytic activity; RNA-directed RNA polymerase activity; peptidase activity; cysteine-type peptidase activity; zine ion binding; hydrolase activity; metal ion binding
Reference
Reference Yang H, Yang M, Ding Y, Liu Y, Lou Z, Zhou Z, Sun L, Mo L, Ye S, Pang H, Gao GF, Anand K, Bartlam M, Hilgenfeld R, Rao Z. The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13190-13195.

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