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Product Summary
Fragment
Full length
Protein Description
SARS Coronavirus Main Proteinase Complexed With Inhibitor
Background
The SARS-CoV main protease, which is a 33.8-kDa protease (also called the 3C-like protease), plays a pivotal role in mediating viral replication and transcription functions through extensive proteolytic processing of two replicase polyproteins, pp1a (486 kDa) and pp1ab (790 kDa).
Protein Classification
Hydrolase
Structure Weight
69623.62 Da
PDBID
1UK4
Method
X-Ray Diffraction
Resolution
2.5 Å
Ligand Chemical Component
Chloroacetone
Reference
Yang H, Yang M, Ding Y, Liu Y, Lou Z, Zhou Z, Sun L, Mo L, Ye S, Pang H, Gao GF, Anand K, Bartlam M, Hilgenfeld R, Rao Z. The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13190-13195.
cDNALength
918