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IDI1 Protein Crystal(CBCRY10)

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Product Summary
Name IDI1 Protein Crystal
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Cat No.CBCRY10
FragmentFull length
Protein DescriptionIsopentenyl-diphosphate delta-isomerase 1
BackgroundIDI1 encodes a peroxisomally-localized enzyme that catalyzes the interconversion of isopentenyl diphosphate (IPP) to its highly electrophilic isomer, dimethylallyl diphosphate (DMAPP), which are the substrates for the successive reaction that results in the synthesis of farnesyl diphosphate and, ultimately, cholesterol. It has been shown in peroxisomal deficiency diseases such as Zellweger syndrome and neonatal adrenoleukodystrophy that there is reduction in IPP isomerase activity.
Protein ClassificationIsomerase
Structure Weight56107.39 Da
MethodX-Ray Diffraction
Resolution2.00 Å
Ligand Chemical ComponentAcetic acid; Aminoethanolpyrophosphate; Magnesium ion; Manganese ion
ReferenceZhang, C., Liu, L., Xu, H., Wei, Z., Wang, Y., Lin, Y., Gong, W. (2007) Crystal structures of human IPP isomerase: new insights into the catalytic mechanism J.Mol.Biol. 366: 1437-1446

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