Interleukin-2 (IL-2) is an immunoregulatory cytokine that binds sequentially to the alpha (IL-2Ralpha), beta (IL-2Rbeta), and common gamma chain (gammac) receptor subunits.
Molecular Description
Protein Classification
Immune System
Structure Weight
40207.9 Da
Polymer
1
Molecule
Interleukin-2
Chain Length
133 amino acids
Polymer
2
Molecule
Interleukin-2 receptor alpha chain
Chain Length
219 amino acids
Crystal Description
PDB ID
1Z92
MMDB ID
33820
Source
E.coli
Method
X-Ray Diffraction
Resolution
2.80 Å
Gene Information
Gene Name
IL2
Synonyms
IL-2; TCGF; lymphokine; T cell growth factor; aldesleukin; interleukin-2; involved in regulation of T-cell clonal expansion; Aldesleukin
Rickert, M., Wang, X., Boulanger, M.J., Goriatcheva, N., Garcia, K.C. (2005) The structure of interleukin-2 complexed with its alpha receptor. Science 308: 1477-1480