IL2 with IL2RA Protein Crystal

Background

Interleukin-2 (IL-2) is an immunoregulatory cytokine that binds sequentially to the alpha (IL-2Ralpha), beta (IL-2Rbeta), and common gamma chain (gammac) receptor subunits.

Protein Classification

Immune System

Structure Weight

40207.9 Da

Polymer

1

Molecule

Interleukin-2

Chain Length

133 amino acids

Polymer

2

Molecule

Interleukin-2 receptor alpha chain

Chain Length

219 amino acids

PDB ID

1Z92

MMDB ID

33820

Source

E.coli

Method

X-Ray Diffraction

Resolution

2.80 Å

Gene Name

IL2

Synonyms

IL-2; TCGF; lymphokine; T cell growth factor; aldesleukin; interleukin-2; involved in regulation of T-cell clonal expansion; Aldesleukin

UniProt ID

P60568

Gene ID

3558

Chromosome Location

4q26-q27

Function

cytokine activity; interleukin-2 receptor binding; protein binding; growth factor activity; kinase activator activity

Gene Name

IL2RA

Synonyms

RP11-536K7.1; CD25; IDDM10; IL2R; TCGFR; Interleukin-2 receptor; OTTHUMP00000019030; OTTHUMP00000044870; interleukin 2 receptor, alpha chain; IL-2-RA; IL2-RA; CD25 antigen; IL2 receptor alpha subunit; TAC antigen; interleukin 2 receptor, alpha

UniProt ID

P60568

Gene ID

3558

Chromosome Location

10p15-p14

Function

cytokine activity; interleukin-2 receptor binding; protein binding; growth factor activity; kinase activator activity

Reference

Rickert, M., Wang, X., Boulanger, M.J., Goriatcheva, N., Garcia, K.C. (2005) The structure of interleukin-2 complexed with its alpha receptor. Science 308: 1477-1480