Creative Biostructure to Present at AACR Annual Meeting 2024 Creative Biostructure to Present at AACR Annual Meeting 2024 | April 5-10, 2024 | Booth #2953 Learn More > Close

PLK4 Protein Crystal(CBCRY56)

Inquiry
Product Summary
Name PLK4 Protein Crystal
Download Datasheet
Cat No.CBCRY56
FragmentPolo box domain
Protein DescriptionPolo-like Kinase 4
BackgroundPolo-like kinase 4 (PLK4) belongs to the polo family of serine/threonine protein kinases. PLK4 localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. PLK4 is involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1.
Protein ClassificationTransferase
Structure Weight64844.43 Da
MethodX-Ray Diffraction
Resolution2.25 Å
Ligand Chemical ComponentSULFATE ION, ANP
ReferenceAtwell S, Burley SK, Houle A, Leon B, Pelletier LA, Sauder JM. Crystal structure of plk4 kinase. No recorded citation in PubMed.

Online Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Inquiry