Inquiry Basket
| Your inquiry basket is currently empty. |
Product Summary
Fragment
Catalytic domain
Protein Description
Protein Tyrosine Phosphatase, Non-receptor Type 1
Background
Tyrosine-protein phosphatase non-receptor type 1 belongs to tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. Tyrosine-protein phosphatase acts as a regulator of endoplasmic reticulum unfolded protein response. It mediates dephosphorylation of EIF2AK3/PERK, and also regulates the hepatocyte growth factor receptor signaling pathway.
Protein Classification
Hydrolase
Structure Weight
37896.55 Da
PDBID
1PTY
Method
X-Ray Diffraction
Resolution
1.85 Å
Ligand Chemical Component
Mg2+, O-PHOSPHOTYROSINE
Reference
Puius YA, Zhao Y, Sullivan M, Lawrence DS, Almo SC, Zhang ZY. Crystal Structure of Protein Tyrosine Phosphatase 1B Complexed With Two Phosphotyrosine Molecules.
cDNALength
1305