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USP7 Protein Crystal(CBCRY35)

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Product Summary
Name USP7 Protein Crystal
Download Datasheet
Cat No.CBCRY35
FragmentResidues 43-560
Protein DescriptionUbiquitin Carboxyl-terminal Hydrolase 7
BackgroundHerpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7), a deubiquitylating enzyme of the ubiquitin-specific processing protease family, specifically deubiquitylates both p53 and MDM2, hence playing an important yet enigmatic role in the p53-MDM2 pathway.
Protein ClassificationHydrolase
Structure Weight121067.00 Da
MethodX-Ray Diffraction
Resolution3.2Å
ReferenceHu, M., Gu, L., Li, M., Jeffrey, P.D., Gu, W., Shi, Y. (2006) Structural Basis of Competitive Recognition of p53 and MDM2 by HAUSP/USP7: Implications for the Regulation of the p53-MDM2 Pathway. Plos Biol. 4: e27-e27

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