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Product Summary
Fragment
Residues 43-560
Protein Description
Ubiquitin Carboxyl-terminal Hydrolase 7
Background
Herpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7), a deubiquitylating enzyme of the ubiquitin-specific processing protease family, specifically deubiquitylates both p53 and MDM2, hence playing an important yet enigmatic role in the p53-MDM2 pathway.
Protein Classification
Hydrolase
Structure Weight
121067.00 Da
PDBID
2F1Z
Method
X-Ray Diffraction
Resolution
3.2Å
Reference
Hu, M., Gu, L., Li, M., Jeffrey, P.D., Gu, W., Shi, Y. (2006) Structural Basis of Competitive Recognition of p53 and MDM2 by HAUSP/USP7: Implications for the Regulation of the p53-MDM2 Pathway. Plos Biol. 4: e27-e27
cDNALength
1566