The phosphodiesterases (PDEs) are a superfamily of enzymes that metabolically inactivate cAMP and cGMP to play key roles in both these aspects of regulation. There are 11 PDE gene families, which differ broadly in specificity and affinity for cAMP and cGMP. An isoform PDE2A2 is supposed to regulates mitochondrial cAMP levels and respiration.
Molecular Description
Protein Classification
Hydrolase
Structure Weight
158085.17 Da
Polymer
1
Molecule
cGMP-dependent 3',5'-cyclic phosphodiesterase
Chain Length
691 amino acids
Crystal Description
PDB ID
3IBJ
MMDB ID
77674
Source
Spodoptera frugiperda
Method
X-Ray Diffraction
Resolution
3.02 Å
Ligand Chemical Component
Mg2+ Zn2+
Gene Information
Gene Name
PDE2A
Synonyms
PDE2A1; PED2A4; cGSPDE; CGS-PDE
UniProt ID
O00408
Gene ID
5138
Chromosome Location
11q13.4
Function
calcium channel activity; cAMP binding; cGMP binding; cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; cyclic-nucleotide phosphodiesterase activity; metal ion binding; protein homodimerization activity
Reference
Reference
Pandit J, Forman MD, Fennell KF, Dillman KS, Menniti FS. Mechanism for the allosteric regulation of phosphodiesterase 2a deduced from the x-ray structure of a near full-length construct. Proc.Natl.Acad.Sci.Usa (2009) 106 p.18225
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