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PDE2A Protein Crystal(CBCRY48)

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Product Summary
Name PDE2A Protein Crystal Download Datasheet
Background
Background The phosphodiesterases (PDEs) are a superfamily of enzymes that metabolically inactivate cAMP and cGMP to play key roles in both these aspects of regulation. There are 11 PDE gene families, which differ broadly in specificity and affinity for cAMP and cGMP. An isoform PDE2A2 is supposed to regulates mitochondrial cAMP levels and respiration.
Molecular Description
Protein ClassificationHydrolase
Structure Weight158085.17 Da
Polymer1
MoleculecGMP-dependent 3',5'-cyclic phosphodiesterase
Chain Length691 amino acids
Crystal Description
PDB ID3IBJ
MMDB ID77674
SourceSpodoptera frugiperda
MethodX-Ray Diffraction
Resolution3.02 Å
Ligand Chemical ComponentMg2+ Zn2+
Gene Information
Gene NamePDE2A
SynonymsPDE2A1; PED2A4; cGSPDE; CGS-PDE
UniProt IDO00408
Gene ID5138
Chromosome Location11q13.4
Functioncalcium channel activity; cAMP binding; cGMP binding; cGMP-stimulated cyclic-nucleotide phosphodiesterase activity了; cyclic-nucleotide phosphodiesterase activity; metal ion binding; protein homodimerization activity
Reference
Reference Pandit J, Forman MD, Fennell KF, Dillman KS, Menniti FS. Mechanism for the allosteric regulation of phosphodiesterase 2a deduced from the x-ray structure of a near full-length construct. Proc.Natl.Acad.Sci.Usa (2009) 106 p.18225

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