PDE2A Protein Crystal

Background

The phosphodiesterases (PDEs) are a superfamily of enzymes that metabolically inactivate cAMP and cGMP to play key roles in both these aspects of regulation. There are 11 PDE gene families, which differ broadly in specificity and affinity for cAMP and cGMP. An isoform PDE2A2 is supposed to regulates mitochondrial cAMP levels and respiration.

Protein Classification

Hydrolase

Structure Weight

158085.17 Da

Polymer

1

Molecule

cGMP-dependent 3',5'-cyclic phosphodiesterase

Chain Length

691 amino acids

PDB ID

3IBJ

MMDB ID

77674

Source

Spodoptera frugiperda

Method

X-Ray Diffraction

Resolution

3.02 Å

Ligand Chemical Component

Mg2+ Zn2+

Gene Name

PDE2A

Synonyms

PDE2A1; PED2A4; cGSPDE; CGS-PDE

UniProt ID

O00408

Gene ID

5138

Chromosome Location

11q13.4

Function

calcium channel activity; cAMP binding; cGMP binding; cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; cyclic-nucleotide phosphodiesterase activity; metal ion binding; protein homodimerization activity

Reference

Pandit J, Forman MD, Fennell KF, Dillman KS, Menniti FS. Mechanism for the allosteric regulation of phosphodiesterase 2a deduced from the x-ray structure of a near full-length construct. Proc.Natl.Acad.Sci.Usa (2009) 106 p.18225