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Product Summary | |
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Name | PDE2A Protein Crystal Download Datasheet |
Background | |
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Background | The phosphodiesterases (PDEs) are a superfamily of enzymes that metabolically inactivate cAMP and cGMP to play key roles in both these aspects of regulation. There are 11 PDE gene families, which differ broadly in specificity and affinity for cAMP and cGMP. An isoform PDE2A2 is supposed to regulates mitochondrial cAMP levels and respiration. |
Molecular Description | |
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Protein Classification | Hydrolase |
Structure Weight | 158085.17 Da |
Polymer | 1 |
Molecule | cGMP-dependent 3',5'-cyclic phosphodiesterase |
Chain Length | 691 amino acids |
Crystal Description | |
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PDB ID | 3IBJ |
MMDB ID | 77674 |
Source | Spodoptera frugiperda |
Method | X-Ray Diffraction |
Resolution | 3.02 Å |
Ligand Chemical Component | Mg2+ Zn2+ |
Gene Information | |
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Gene Name | PDE2A |
Synonyms | PDE2A1; PED2A4; cGSPDE; CGS-PDE |
UniProt ID | O00408 |
Gene ID | 5138 |
Chromosome Location | 11q13.4 |
Function | calcium channel activity; cAMP binding; cGMP binding; cGMP-stimulated cyclic-nucleotide phosphodiesterase activity了; cyclic-nucleotide phosphodiesterase activity; metal ion binding; protein homodimerization activity |
Reference | |
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Reference | Pandit J, Forman MD, Fennell KF, Dillman KS, Menniti FS. Mechanism for the allosteric regulation of phosphodiesterase 2a deduced from the x-ray structure of a near full-length construct. Proc.Natl.Acad.Sci.Usa (2009) 106 p.18225 |