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Product Summary
Fragment
Residues 215-900
Protein Description
Phosphodiesterase 2
Background
The phosphodiesterases (PDEs) are a superfamily of enzymes that metabolically inactivate cAMP and cGMP to play key roles in both these aspects of regulation. There are 11 PDE gene families, which differ broadly in specificity and affinity for cAMP and cGMP. An isoform PDE2A2 is supposed to regulates mitochondrial cAMP levels and respiration.
Protein Classification
Hydrolase
Structure Weight
158085.17 Da
PDBID
3IBJ
Method
X-Ray Diffraction
Resolution
3.02 Å
Ligand Chemical Component
Mg2+ Zn2+
Reference
Pandit J, Forman MD, Fennell KF, Dillman KS, Menniti FS. Mechanism for the allosteric regulation of phosphodiesterase 2a deduced from the x-ray structure of a near full-length construct. Proc.Natl.Acad.Sci.Usa (2009) 106 p.18225
cDNALength
2823