PTP1B Protein Crystal(CBCRY52)

Inquiry

Product Summary
Name	PTP1B Protein Crystal
	Download Datasheet
Cat No.	CBCRY52
Fragment	Catalytic domain
Protein Description	Protein Tyrosine Phosphatase, Non-receptor Type 1
Background	Tyrosine-protein phosphatase non-receptor type 1 belongs to tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. Tyrosine-protein phosphatase acts as a regulator of endoplasmic reticulum unfolded protein response. It mediates dephosphorylation of EIF2AK3/PERK, and also regulates the hepatocyte growth factor receptor signaling pathway.
Protein Classification	Hydrolase
Structure Weight	37896.55 Da
Method	X-Ray Diffraction
Resolution	1.85 Å
Ligand Chemical Component	Mg2+, O-PHOSPHOTYROSINE
Reference	Puius YA, Zhao Y, Sullivan M, Lawrence DS, Almo SC, Zhang ZY. Crystal Structure of Protein Tyrosine Phosphatase 1B Complexed With Two Phosphotyrosine Molecules.

Online Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.