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PTP1B Protein Crystal(CBCRY52)

Product Summary
Name PTP1B Protein Crystal Download Datasheet
Background
Background Tyrosine-protein phosphatase non-receptor type 1 belongs to tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. Tyrosine-protein phosphatase acts as a regulator of endoplasmic reticulum unfolded protein response. It mediates dephosphorylation of EIF2AK3/PERK, and also regulates the hepatocyte growth factor receptor signaling pathway.
Molecular Description
Protein ClassificationHydrolase
Structure Weight37896.55 Da
Polymer1
MoleculePROTEIN TYROSINE PHOSPHATASE 1B
Chain Length321 amino acids
Crystal Description
PDB ID1PTY
MMDB ID57182
SourceE.coli
MethodX-Ray Diffraction
Resolution1.85 Å
Ligand Chemical ComponentMg2+, O-PHOSPHOTYROSINE
Gene Information
Gene NamePTPN1
SynonymsPTP1B
UniProt IDP18031
Gene ID5770
Chromosome Location20q13.1-q13.2
Functionenzyme binding; ephrin receptor binding; poly(A) RNA binding; protein kinase binding; protein tyrosine phosphatase activity; receptor tyrosine kinase binding; zinc ion binding
Reference
Reference Puius YA, Zhao Y, Sullivan M, Lawrence DS, Almo SC, Zhang ZY. Crystal Structure of Protein Tyrosine Phosphatase 1B Complexed With Two Phosphotyrosine Molecules.

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