Background

Pyrroline-5-carboxylate reductase (P5CR) is a universal housekeeping enzyme that catalyzes the reduction of Delta(1)-pyrroline-5-carboxylate (P5C) to proline using NAD(P)H as the cofactor. The enzymatic cycle between P5C and proline is very important for the regulation of amino acid metabolism, intracellular redox potential, and apoptosis

Protein Classification

Oxidoreductase

Structure Weight

149791.08 Da

Polymer

1

Molecule

Pyrroline-5-carboxylate reductase 2

Chain Length

277 amino acids

PDB ID

2GR9

MMDB ID

41570

Source

E.coli

Method

X-Ray Diffraction

Resolution

3.1Å

Ligand Chemical Component

Magnesium ion; Sulfate ion

Gene Name

PYCR2

Synonyms

P5CR2; OTTHUMP00000035614; pyrroline 5-carboxylate reductase isoform; EC 1.5.1.2; P5C reductase 2; pyrroline-5-carboxylate reductase family, member 2; FLJ54750; RP4-559A3.4

UniProt ID

Q96C36

Gene ID

29920

Chromosome Location

1q42.12

Function

catalytic activity; binding; pyrroline-5-carboxylate reductase activity; Oxidoreductase activity

Reference

Meng, Z., Lou, Z., Liu, Z., Li, M., Zhao, X., Bartlam, M., Rao, Z. (2006) Crystal structure of human pyrroline-5-carboxylate reductase J.Mol.Biol. 359: 1364-1377