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PYCR2 Protein Crystal(CBCRY25)

Product Summary
Name PYCR2 Protein Crystal Download Datasheet
Background Pyrroline-5-carboxylate reductase (P5CR) is a universal housekeeping enzyme that catalyzes the reduction of Delta(1)-pyrroline-5-carboxylate (P5C) to proline using NAD(P)H as the cofactor. The enzymatic cycle between P5C and proline is very important for the regulation of amino acid metabolism, intracellular redox potential, and apoptosis
Molecular Description
Protein ClassificationOxidoreductase
Structure Weight149791.08 Da
MoleculePyrroline-5-carboxylate reductase 2
Chain Length277 amino acids
Crystal Description
MMDB ID41570
MethodX-Ray Diffraction
Ligand Chemical ComponentMagnesium ion; Sulfate ion
Gene Information
Gene NamePYCR2
SynonymsP5CR2; OTTHUMP00000035614; pyrroline 5-carboxylate reductase isoform; EC; P5C reductase 2; pyrroline-5-carboxylate reductase family, member 2; FLJ54750; RP4-559A3.4
UniProt IDQ96C36
Gene ID29920
Chromosome Location1q42.12
Functioncatalytic activity; binding; pyrroline-5-carboxylate reductase activity; Oxidoreductase activity
Reference Meng, Z., Lou, Z., Liu, Z., Li, M., Zhao, X., Bartlam, M., Rao, Z. (2006) Crystal structure of human pyrroline-5-carboxylate reductase J.Mol.Biol. 359: 1364-1377

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