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PYCR2 Protein Crystal(CBCRY25)

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Product Summary
Name PYCR2 Protein Crystal Download Datasheet
Background
Background Pyrroline-5-carboxylate reductase (P5CR) is a universal housekeeping enzyme that catalyzes the reduction of Delta(1)-pyrroline-5-carboxylate (P5C) to proline using NAD(P)H as the cofactor. The enzymatic cycle between P5C and proline is very important for the regulation of amino acid metabolism, intracellular redox potential, and apoptosis
Molecular Description
Protein ClassificationOxidoreductase
Structure Weight149791.08 Da
Polymer1
MoleculePyrroline-5-carboxylate reductase 2
Chain Length277 amino acids
Crystal Description
PDB ID2GR9
MMDB ID41570
SourceE.coli
MethodX-Ray Diffraction
Resolution3.1Å
Ligand Chemical ComponentMagnesium ion; Sulfate ion
Gene Information
Gene NamePYCR2
SynonymsP5CR2; OTTHUMP00000035614; pyrroline 5-carboxylate reductase isoform; EC 1.5.1.2; P5C reductase 2; pyrroline-5-carboxylate reductase family, member 2; FLJ54750; RP4-559A3.4
UniProt IDQ96C36
Gene ID29920
Chromosome Location1q42.12
Functioncatalytic activity; binding; pyrroline-5-carboxylate reductase activity; Oxidoreductase activity
Reference
Reference Meng, Z., Lou, Z., Liu, Z., Li, M., Zhao, X., Bartlam, M., Rao, Z. (2006) Crystal structure of human pyrroline-5-carboxylate reductase J.Mol.Biol. 359: 1364-1377

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