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Product Summary
Product Overview
The encapsulation of ATP in liposomes markedly promotes its effectiveness by preventing the hydrolysis by extracellular enzymes, increasing ATP circulation time and enhancing its intracellular penetration. ATP liposomes can be used in various models such as myocardial, liver, retina and wound healing ischemia. Studies have shown the ability of liposomal encapsulated ATP to prevent cell death and tissue dysfunction following ischemic events. The concentration of encapsulated ATP is 0.5μmol/vial.
Lipid Composition
DOTAP/DOPC/CHOL/DSPE-mPEG2000/Rhod-PE (0.9/0.075/0.435/0.075/0.015 μmol/vial) DOTAP: 1,2-dioleoyl-3-trimethylammonium-propane (chloride salt) DOPC: 1,2-dioleoyl-sn-glycero-3-phosphocholine CHOL: Cholesterol Rhod PE: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(lissamine rhodamine B sulfonyl) (ammonium salt) (Rhod PE) DSPE-mPEG2000: 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethyleneglycol)-2000] (ammonium salt)/CAS: 474922-77-5
Form
Lyophilized Powder
Storage Buffer
PBS, pH 7.4 with trehalose as lyoprotectant
Concentration
Lipid Concentration 1.5 μmol/vial
Stability
6 months
Storage
-20°C