Product Overview
Doxorubicin HCl is loaded into PEGylated liposomes composed of HSPC/CHOL/mPEG2000-DSPE (56.2:38.5:5.3 mol/mol) with ammonium gradient by the active loading approach. The liposomes are prepared to very high quality with consistent lot-lot characteristics. Narrow particle size distribution and high drug encapsulation efficiency.<br />Lipid composition: HSPC/CHOL/mPEG2000-DSPE (56.2:38.5:5.3 mol/mol)<br />Mean particle size: 85 nm (80 - 90 nm)<br />Encapsulation efficiency:> 95% (typically 98%)
Application
Liposome production; Synthetic lipid
Storage Buffer
External solution: 10% sucrose, 10 mM histidine, pH 6.5
Concentration
Lipid concentration: 40.0 mM<br />Doxorubicin HCl: 4.0 mg/mL
Stability
6 Month for unopened vials.
Synonyms
HSPC; hydrogenated phosphatidylcholine (Soy); CHOL; cholesterol; mPEG2000-DSPE