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Liposomes Technology

Creative Biostructure has been focused on the development of liposome technologies for years, and our rich experience makes us an expert in liposome preparation and manufacuring. The ultimate goal of our Liposomes Platform is to provide you the best liposomes services all the way from custom liposome production, analysis and characterization to the application.

Liposomes Technology Figure 1. Different types of liposomes in drug delivery systems. (Frontiers in Pharmacology, 2015)

Liposomes are small artificial spherical vesicles which are normally made of natural non-toxic phospholipids and cholesterols. Creative Biostructure has developed the Liposomes Technology with plenty of advantages:

  • Non toxic, biocompatible, and completely biodegradable;
  • Enhanced bioactivity and efficacy;
  • Site avoidance effect;
  • Increased stability via encapsulation processes;
  • Reduced toxicity of encapsulated drugs;
  • Flexibility for active targeting.

Novel liposome designs become more and more important because it manipulates the solubility of encapsulated small organic molecules, protects the embedded agents from degradation, and achieves site-specific delivery. Creative Biostructure provides novel liposome formulations with different properties to both academic and industrial clients. Depending on the formulation techniques and lipid composition, various functional liposomes are available for use in research development, including immunoliposomes, proteoliposomes, magnetic liposomes, fluorescent liposomes, and pH sensitive liposomes.

Same liposome preparation methods can be utilized regardless of the composition. The general 4-step process to prepare liposome involves drying down the lipids, dispersing the lipids, purification of liposomes and analysis of the final products. Creative Biostructure is also able to prepare liposomes through different methods including sonication, ultrasonication, french pressure cell, extrusion, membrane extrusion and lipid film hydration.

Creative Biostructure goes beyond convention liposome preparation and offers analytical method developments as well. We provide various analysis services to characterize liposome-based products physically and chemically, to determine the liposome size, shape, lamellarity, lipid composition quantification, encapsulation efficiency, etc.


Thanks to the amphipathic characters, liposomes are considered entensively as promising carriers for drug delivery. Moreover, liposomes have achieved more clinical acceptance by the ability of long circulation residence time and precise targeting. In recent years, liposomes technology has successfully been applied in a broad range of pharmaceutical applications such as cancer therapy, antibacterial, antifungal, immunomodulation, diagnostics, and vaccines.

Creative Biostructure is more than happy to be your partner specialized in the research field of liposomes and willing to provide the first-class liposome services. Please feel free to contact us for a detailed quote.

Ordering Process

Ordering Process

References

  1. L. Sercombe, et al. (2015). Advances and challenges of liposome assisted drug delivery. Frontiers in Pharmacology, 6: A286.
  2. N. Monteiro, et al. (2014). Liposomes in tissue engineering and regenerative medicine. J. R. Soc. Interface, 11: 0459.
  3. A. Akbarzadeh, et al. (2013). Liposome: classification, preparation, and applications. Nanoscale Research Letters, 8: 102.

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