Liposome Services

Creative Biostructure has been focused on the development of liposome technologies for years, and our rich experience makes us an expert in liposome preparation and manufacturing. The goal of our liposome platform is to provide you liposome services of high quality from custom liposome production, analysis, and characterization to the application.

Figure 1. Different types of liposomes in drug delivery systems. (Frontiers in Pharmacology, 2015)

Liposomes are small artificial spherical vesicles that are normally made of natural non-toxic phospholipids and cholesterols. Creative Biostructure has developed Liposome Technology with plenty of advantages:

• Nontoxic, biocompatible, and completely biodegradable
• Enhanced bioactivity and efficacy
• Site avoidance effect
• Increased stability via encapsulation processes
• Reduced toxicity of encapsulated drugs
• Flexibility for active targeting

Novel liposome designs become more and more important because it manipulates the solubility of encapsulated small organic molecules, protects the embedded agents from degradation, and achieves site-specific delivery. Creative Biostructure provides novel liposome formulations with different properties to both academic and industrial clients. The general 4-step process to prepare liposomes involves drying down the lipids, dispersing the lipids, purification of liposomes and analysis of the final products. Creative Biostructure goes beyond convention liposome preparation and offers analytical method developments as well.

Liposome Services at Creative Biostructure

Why Partner with Creative Biostructure?

• Depending on the formulation techniques and lipid composition, various functional liposomes can be produced for use in research development, such as immunoliposomes, thermally sensitive liposomes, fluorescent liposomes, multivesicular liposomes, and photo-activated liposomes.
• Creative Biostructure is also able to prepare liposomes through different methods including sonication, ultrasonication, French pressure cell, extrusion, membrane extrusion and lipid film hydration.
• We provide various analysis services to characterize liposome-based products physically and chemically, to determine the liposome size, shape, lamellarity, lipid composition quantification, encapsulation efficiency, etc.

Thanks to the amphipathic characters, liposomes are considered extensively as promising carriers for drug delivery. Moreover, liposomes have achieved more clinical acceptance by the ability of long circulation residence time and precise targeting. In recent years, liposome technology has successfully been applied in a broad range of pharmaceutical applications such as cancer therapy, antibacterial, antifungal, immunomodulation, diagnostics, and vaccines.

Creative Biostructure is more than happy to be your partner specialized in the research field of liposomes and willing to provide first-class liposome services. Please feel free to contact us for more information or a detailed quote.

References

1. Sercombe L, et al. Advances and challenges of liposome assisted drug delivery. Frontiers in Pharmacology. 2015, 6: 286.
2. Monteiro N, et al. Liposomes in tissue engineering and regenerative medicine. Journal of the Royal Society Interface. 2014, 11(101): 20140459.
3. Akbarzadeh A, et al. Liposome: classification, preparation, and applications. Nanoscale Research Letters. 2013, 8(1): 102.