Pharmaceutical Development

Creative Biostructure has decade years of experience in the development of drug delivery system. Noticing that cyclodextrins is a novel technology to achieve target drug delivery, we have developed a reliable liposome platform to facilitate such effort.

Why cyclodextrins are used for drug delivery?

The molecules associated with poor physicochemical and biopharmaceutical properties are difficult to formulate. Owing to cyclodextrins’ hydrophobic cavity and hydrophilic outer surface, cyclodextrins as are often used as one of the molecular host in pharmaceutical formulation increase the bioavailability of poorly water soluble or unstable drugs. In the nearest few decades, the applications of cyclodextrins and their derivatives in the pharmacy have caught interest because of their non-toxicity, increased solubility, dissolution rate and bioavailability of the loaded drugs, and larger loading dose Creative Biostructure is very experienced in helping our client to customize cyclodextrin in main pharmaceuticals applications as follows:

• Cyclodextrins as APIs: Pure cyclodextrins are used as pharmaceutical ingredients by functioning as a new class of antibiotics, reversal agents and NCEs that targets diseases on a wide therapeutic range, such as anticancer therapy, cardiovascular diseases, life-saving antidotes or neurodegenerative illnesses.
• Cyclodextrins in drug delivery systems: Cyclodextrins could be used as drug carriers like liposomes, it has advantages in different drug delivery route including ophthalmic, nasal transdermal, rectal and oral drug development. Cyclodextrin modification could achieve increased solubility for a specific drug molecule. More importantly, double loaded technology (eg. Drug-in-Cyclodextrin-in-Liposome) combines relative advantages of CDs and liposomes into one system to prolong drug release process, increase target release, and significantly enhance drug-loading capacity. In particular, this double loading system is suitable for the delivery of hydrophobic drugs which also possess volatility. Besides liposome, this method also could be combined with other nanocarriers.
• Cyclodextrins enabled injections: Cyclodextrins used in injectable formulations have advantages with desirable physical and chemical stability, isosmotic property, pH close to interstitial liquid over formulations that contain detergents like TWEEN or co-solvents.
• Cyclodextrins in biological products: Cyclodextrins are used as replacements for traditional and less safe excipients (e.g. detergents) in formulations of highly concentrated antibodies to overcome associated challenges in terms of optimization of production processes, chemical and physical stability of the final products, preventing aggregation and solution viscosity.

Creative Biostructure closely follows the latest technology in drug delivery system and we offer high-quality service for cyclodextrin and CD-based liposome drug delivery system development. We can customize cyclodextrins according to your unique demands. Besides, our comprehensive equipment will offer the one-stop solution for property analysis. The services in our company share a competitive price and rapid turnaround.

Creative Biostructure has always had strong presence in providing perfect manufacture and analysis service for liposome. We will be your best cooperator based on our professional technical support and advanced apparatus. Please contact us for more details and find out how it helps to the new product development.

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References

1. Nadiah Zafar, Hatem Fessi, Abdelhamid Elaissari. (2014) Cyclodextrin containing biodegradable particles: From preparation to drug delivery applications. International Journal of Pharmaceutics. 461: 351-366
2. Bina Gidwani, Amber Vyas. (2015) A Comprehensive Review on Cyclodextrin-Based Carriers for Delivery of Chemotherapeutic Cytotoxic Anticancer Drugs. BioMed Research International. doi: http://dx.doi.org/10.1155/2015/198268
3. Gharib, R., Auezova, L., Charcosset, C., Greige-Gerges, H., (2016) Drug-in-cyclodextrin-inliposomes as a carrier system for volatile essential oil components: application to anethole, Food Chemistry, http://dx.doi.org/10.1016/j.foodchem.2016.09.110