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Creative Biostructure offers liposome manufacturing services to elevate the current industrial standard with our cutting-edge technologies and approaches. Our experts are specialized in liposome manufacturing and characterization, and have already established the transfersome platform to transport drug through skin.
How Transfersomes Work
Different from other types of liposomes, transfersomes are mainly developed for transdermal drug delivery systems. Transfersomes are composed of self-assembled phospholipids (eg. phosphatidylcholine) and edge activators (such as a biocompatible surfactant or an amphiphilic drug) which increases lipid bilayer flexibility and permeability. Therefore, transfersomes can deform and pass through narrow constriction (from 5 to 10 times less than their own diameter) to underlying viable skin without measurable loss due to transdermal osmotic gradients which is developed by skin penetration barrier.
Transfersomes are an ideal choice for drug development of non-invasive therapeutic use. Based on the capability of increasing the transdermal flux, prolonging the release and improving the site specificity of bioactive molecules, transfersome has become a potential candidate for both systemic and topical delivery of drugs.
However, chemical instability, phospholipid impurity, and expensive formulation limit the manufacturing of transfersomes. Creative Biostructure can overcome these obstacles to support the preparation using our professional knowledge and unique technologies.
Figure 1. Schematic presentation of mechanism of action of transfersome in transdermal delivery of anticancer agent. (Nano reviews & experiments, 2017)
Transfersome is a good carrier option to deliver drug into the skin layers for the treatment of skin cancers. Current application of transfersomes has been presented in treatment of actinic keratosis, basal cell carcinoma, squamous cell carcinoma, melanoma, and Kaposi’s sarcoma. In the future, it is likely that more transfersome applications will be developed based on its versatile encapsulating ability for proteins, anti-cancer drugs, anti-fungal drugs, analgesics, anesthetics, corticosteroids, sex hormone, insulin, albumin, herbal drugs, NSAIDS, interferons and more.
Creative Biostructure offers comprehensive services including transferosomes manufacture and analysis.
Creative Biostructure persists in the best-quality service providing. Equipped with the latest expertise and advanced facilities, we can customize projects which completely meet your requirements. Please contact us for more information.