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SARS-CoV-2 has similar structural features to other coronaviruses. Coronavirus particles have four main structural proteins, namely membrane (M) protein, nucleocapsid (N) protein, spike (S) protein, and envelope (E) protein, and several accessory proteins. Non-infectious virus-like particles (VLPs) displaying crucial viral proteins can be utilized to investigate the structural properties of natural viruses. Besides, VLPs do not contain any viral genetic material and have the potential to trigger a powerful immune response, offering a much safer option for vaccine development.
Figure 1. Structure of SARS-CoV-2. (Kim D, et al., 2020)
In the current continuous outbreak of SARS-CoV-2 / COVID-19, as an advanced VLP supplier, Creative Biostructure provides several VLP products in the family Coronaviridae. Currently, we have successfully created SARS-CoV-2 VLPs composed of M, N, S, and E in mammalian cells. Listed below are some of our COVID-19 related VLP products.
We offer highly purified COVID-19 related VLP products as antigens for research use only, mostly using a mammalian expression system. Creative Biostructure has rich experience in the production of VLPs and can provide custom VLP synthesis services according to your experimental goals.
In addition, Creative Biostructure has established a dedicated coronavirus service platform to assist researchers in basic research on coronavirus bioinformatics analysis, viral particle identification and characterization, coronavirus-related protein interaction analysis, and protein structural analysis. We also provide preclinical antiviral drug discovery and vaccine development services. Please do not hesitate to contact us for further information or a detailed quote.
Kim D, et al. The architecture of SARS-CoV-2 transcriptome. Cell. 2020, 181(4): 914-921. e10.