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X-ray crystallography, nuclear magnetic resonance (NMR) and Cryo-electron microscopy (Cryo-EM) are three of the most predominant techniques in structure biology. They are powerful tools that help structural biologists get an insight into the bioprocess mechanism. NMR is a non-destructive method which providess information on chemical structure and dynamics with atomic resolution. Unlike solution-state NMR, which is good at resolving small protein structure and obtaining dynamic information of soluble materials, solid-state NMR (ssNMR) is a powerful technique for the characterization of solid materials. With solid-state NMR methods, information about structure symmetry, dynamics, and interactions of molecules and complexes can be obtained.
With the recent development of the solid-state NMR technique, high-resolution spectra can be obtained in combination of of cross polarization (CP) and magic angle spinning (MAS) techniques. Besides, solid-state NMR is a powerful and complementary tool to Raman and X-Ray Diffraction (XRD) for polymorph characterization.
Fig. 1 Solid-state NMR procedure.
With superior expertise on NMR spectroscopy, Creative Biostructure provides high quality solid-state NMR services for analysis of pharmaceutical molecules, polymers, glasses, and biosolids. Our featured one-stop service covers every step from sample preparation to data collection and analysis.
At Creative Biostructure, the following solid-state NMR experiments can be performed:
Creative Biostructure promises to work closely with our customers to provide excellent services from sample preparation to ssNMR data collection and analysis. We aim for providing our customers with the highest quality NMR data.
Please feel free to contact us for a detailed quote.