Creative Biostructure has been focusing on nanodiscs technology research for years，our team has established an advanced Mempro™ nanodiscs analysis platform to provide various services to meet client’s requirements.
Nanodiscs are soluble nanoscale phospholipid bilayers, encircled and stabilized by membrane scaffold proteins (MSP). They have been proven to be powerful and promising tools to study membrane proteins. Compared with other strategies, such as liposomes, bicelles and detergent micelles, nanodiscs are more close to native environment where proteins remain monodisperse and active. Creative Biostructure offers a variety of approaches for nanodisc analysis, including surface plasmon resonance (SPR), Nuclear magnetic resonance (NMR) spectroscopy, electron paramagnetic resonance (EPR), native Polyacrylamide Gel Electrophoresis (PAGE), free flow electrophoresis (FFE) and Chromatography.
Figure 1. Single-particle cryo-EM of unliganded TRPV1 in lipid nanodisc. (Gao, Y. 2016)
Creative Biostructure also provides other various Mempro™ nanodisc technology services. Please feel free to contact us for more detailed quote.
Gao, Y. (2016). “TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action”. Nature.
Justesen, B. H. (2014). “Chromatographic and electrophoretic methods for nanodisc purification and analysis”. Reviews in Analytical Chemistry, 33(3), 165-172.