Exosome Drug Delivery Solutions
Struggling with poor drug bioavailability, off-target toxicity, and rapid degradation of your nucleic acid or protein therapeutics? Conventional delivery methods often fail to protect valuable payloads or reach the desired tissue, limiting therapeutic efficacy.
We provide end-to-end exosome drug delivery solutions designed to overcome these critical challenges. We leverage our advanced engineering platforms to transform exosomes into precision nanocarriers. Our service safely transports your specific payload—including siRNA, mRNA, ASO, proteins, and small molecules—directly to target cells, accelerating your drug development pipeline.
The Advantage of Exosome
Why are pharmaceutical and biotech leaders turning to exosomes? Unlike synthetic nanoparticles, exosomes are natural, cell-derived carriers that act as the body's own intercellular communication system. This biological origin provides critical, built-in advantages:
- Inherent Biocompatibility: As a natural vehicle, exosomes exhibit minimal immunogenicity and low toxicity, offering a superior safety profile.
- Natural Targeting: Exosomes possess intrinsic surface proteins (e.g., tetraspanins, integrins) that can guide them to specific recipient cells.
- Payload Protection: The exosome's lipid bilayer naturally protects sensitive cargo (like RNA and proteins) from enzymatic degradation in the bloodstream.
- Biological Barrier Penetration: Exosomes are uniquely capable of crossing complex biological barriers, including the challenging blood-brain barrier (BBB), opening doors for new therapeutic possibilities.
Our platform harnesses these powerful natural benefits and enhances them with precision engineering to create a best-in-class drug delivery vehicle.
Figure 1. Exosome structure and composition, including proteins (membrane-bound and soluble), lipids, and nucleic acids. (Liang Y, et al., 2021)
Our End-to-End Drug Delivery Capabilities
We offer a fully integrated suite of services to take your therapeutic concept from feasibility to in vivo validation. The table below outlines our comprehensive capabilities, which can be engaged as a complete package or as standalone modules to fit your specific needs.
| Service Pillar | Key Services & Technologies We Provide |
|---|---|
| Vehicle Production & Purification | We provide scalable, reproducible exosome production from a diverse range of qualified cell sources, including MSCs and custom lines. Our downstream purification process is optimized for high purity and yield, utilizing advanced, gentle techniques such as Tangential Flow Filtration (TFF) for concentration and Size Exclusion Chromatography (SEC) for high-resolution separation, ensuring a final product free from contaminating proteins and debris. |
| Payload & Targeting Engineering | This is the core of our customization. We employ proprietary methods for the efficient loading of diverse cargos, including nucleic acids (siRNA, mRNA), proteins/peptides, and small molecules. Simultaneously, we engineer the exosome surface for precision targeting, functionalizing it with antibodies, peptides, or targeting ligands to ensure active delivery to your specific cell or tissue type. |
| Advanced QC & Analytics | We deliver data, not just vesicles. Our comprehensive QC analytics provide a complete biophysical and molecular profile. This includes particle size and concentration (NTA, nFCM), morphological analysis (TEM), and full surface marker profiling (Western Blot, FACS). We also provide robust quantification of your encapsulated payload, ensuring batch-to-batch consistency and quality. |
| Functional & In Vivo Validation | We confirm that your engineered exosome works as intended. Our functional assays validate therapeutic potential, starting with in vitro cellular uptake studies and payload release kinetics. We then move to comprehensive in vivo models to assess biodistribution, pharmacokinetics, and efficacy, utilizing our advanced fluorescent and bioluminescent exosome tracking services to visualize delivery in real-time. |
Drug Delivery Applications We Support
Our platform is payload-agnostic and fully customizable to support a diverse range of next-generation therapeutics. We provide specialized development and validation for the following payload classes.
Exosome RNA Delivery (siRNA, mRNA, miRNA, circRNA)
We solve the primary challenge for RNA therapeutics: safe and effective delivery. Our platform protects delicate RNA molecules from RNase degradation in circulation. We engineer exosomes to efficiently encapsulate your RNA cargo and deliver it to the cytoplasm of target cells, enabling powerful applications in gene silencing (siRNA), protein replacement therapy (mRNA), or modulation of cellular pathways (miRNA/circRNA).
Exosome ASO Delivery
Antisense oligonucleotides (ASOs) hold immense promise but suffer from poor cellular uptake and rapid clearance. Our exosome delivery system acts as a "Trojan horse," masking the ASO's charge and facilitating its entry into cells. This dramatically enhances ASO stability and intracellular concentration, unlocking the potential for targeted gene knockdown in tissues previously considered undruggable.
Exosome Small Molecule Delivery
We enhance the therapeutic index of your small molecule drugs, particularly hydrophobic compounds or potent cytotoxics (e.g., chemotherapeutics). By loading these molecules into exosomes, we improve their solubility, alter their pharmacokinetic profile, and utilize active targeting to increase drug accumulation at the disease site (e.g., tumors) while significantly reducing systemic, off-target toxicity.
Exosome Protein & Peptide Delivery
Our platform enables the delivery of large-molecule protein and peptide therapeutics. This includes functional enzymes for replacement therapies, therapeutic antibodies, or bioactive peptides. The exosome vehicle protects the protein cargo from proteolysis in the bloodstream and facilitates its transport across cell membranes to reach intracellular targets, a feat often impossible for the protein alone.
Advantages of Our Drug Delivery Platform
Partner with us to leverage a platform built for precision, scalability, and accelerated results.
Exosome Engineering & Loading Technologies
Our advanced cargo loading technologies ensure high encapsulation efficiency and protect your payload's integrity. Combined with our robust surface display and functionalization techniques, we achieve superior targeting and enhanced therapeutic potency.
Exosome Characterization and Analysis
We provide more than just manufacturing. Our comprehensive characterization suite and deep functional validation capabilities mean you receive a fully characterized product. We deliver actionable data, not just vesicles, proving payload integrity, uptake, and in vivo activity.
Exosome Manufacturing
We manage your entire project pipeline under one roof. From initial exosome isolation and custom engineering to rigorous QC, functional in vivo validation, and scalable, GMP-compliant manufacturing, we are your single, reliable partner from discovery to the clinic.
Application Spotlight: Targeted siRNA Delivery via Engineered Exosomes
This concise analysis shows how our core platform technologies are used to solve major therapeutic challenges, as demonstrated in landmark research.
Featured Technologies:
- Exosome Nucleic Acid Loading
- Exosome Surface Engineering for Targeting
Literature Interpretation:
This seminal paper provides a clear blueprint for targeting "undruggable" oncogenes like KRAS in pancreatic cancer.
Researchers first loaded exosomes with specific siRNA to target the KRAS G12D mutation. To ensure the siRNA reached its destination, they engineered the exosome surface with a targeting peptide.
The results were definitive: these engineered exosomes successfully silenced the target gene in vivo, suppressed tumor growth, and significantly increased survival in models, demonstrating a potency that traditional liposomes could not achieve.
Figure 2. iExosomes specifically target KRAS G12D expression. (Kamerkar S, et al., 2017)
Start Your Drug Delivery Project
We make getting started straightforward. Our process is designed to be collaborative and transparent, ensuring your project goals are met at every stage.
How It Works: Our Project Pathway
Our client engagement follows a clear, four-step process from concept to delivery.
Figure 3. Project Workflow for Exosomes Drug Delivery Service. (Creative Biostructure)
Ready to revolutionize your therapeutic strategy? Our scientific team is available for a free consultation to discuss your specific project goals and challenges. Let's work together to unlock the potential of exosome delivery for your payload.
References
- Liang Y, Duan L, Lu J, et al. Engineering exosomes for targeted drug delivery. Theranostics. 2021 Jan 1;11(7):3183-3195.
- Kamerkar S, LeBleu VS, Sugimoto H, et al. Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer. Nature. 2017 Jun 22;546(7659):498-503.
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